The ability to use wild cards effectively is another crucial component of using card combinations. To create legitimate sets and runs, wild cards can be used in place of any 3 paatiother card. In order to fill in gaps in their sets & runs and improve their odds of outlasting their opponents, players can strategically employ wild cards. To effectively use card combinations, you must be able to identify possible combinations in your hand with speed and make calculated decisions about which cards to keep and which to discard.